The series follows a former Syracuse, New York police detective named Carrie Wells, who has hyperthymesia, a rare medical condition that gives her the ability to remember everything. She is reluctantly asked by her former boyfriend and one-time partner to join his homicide unit after he asks for help with solving a case.Rare medical condition? From what I hear, this is a very common condition, and a very common cause of divorce. The wife remembers every fault her husband has, and every mistake he has ever made. Plus all of his relatives and friends. She cannot seem to remember to keep the fridge stocked with beer or to check the oil in the car, but she remembers in painful detail everything that she believes that he is supposed to be doing.
In the TV show, no man can stand to be around Carrie Wells for very long. No one explains why. For those who have been down that road, no explanation is necessary.